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Fasudil treatment in adult reverses behavioural changes and brain ventricular enlargement in Oligophrenin-1 mouse model of intellectual disability

• Hamid Meziane³,*,
• Malik Khelfaoui¹,²,*,
• Noemi Morello⁴,
• Bassem Hiba⁵,
• Eleonora Calcagno⁴,
• Sophie Reibel-Foisset⁶,
• Mohammed Selloum³,
• Jamel Chelly¹,³,
• Yann Humeau²,
• Fabrice Riet³,
• Ginevra Zanni⁷,
• Yann Herault³,
• Thierry Bienvenu¹,
• Maurizio Giustetto⁴ and
• Pierre Billuart¹

for publishing a new article in Human Molecular Genetics, using our Elevated Plus Maze.

1 Institut Cochin, INSERM U1016, CNRS UMR8104, Paris Descartes University, Paris, 75014, France.

2 Institut interdisciplinaire de neuroscience, CNRS UMR5297, University of Bordeaux, Bordeaux, 33077, France.

3 PHENOMIN, Institut Clinique de la Souris, ICS; GIE CERBM, Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS, UMR7104, INSERM, U964, University of Strasbourg, F-67404 Illkirch-Graffenstaden, France

4 University of Torino, Department of Neuroscience « Rita Levi Montalcini », National Institute of Neuroscience-Italy, Torino, 10126, ITALY.

5 Centre de Résonance Magnétique des Systèmes Biologiques, UMR 5536 CNRS, Université de Bordeaux, 33077, BORDEAUX.

6 Chronobioton, CNRS, Universite Strasbourg, UMS3415, Strasbourg, 67084 France.

7 Laboratory of Molecular Medicine, Unit of Neuromuscular and Neurodegenerative Disorders, Department of Neurosciences, Bambino Gesù Children’s Hospital, IRCCS, 00165, Rome, Italy.